COVID-19 vaccination drive might be watershed moment for future model of public health delivery. For a country like India with its vast population, vaccines should be leveraged to preserve the health system from future burden and protection, especially the vulnerable and elderly. India is known to carry high vulnerability quotient in terms of high prevalence of diabetes, cardiovascular diseases, obese population, respiratory illnesses, and a large aging population. The burden of vaccine preventable diseases on the healthcare infrastructure, financial capital, and the economy at-large is skyrocketing, in that context investing in adult immunization is not just a moral but a central economic one. USIN’s initiative on life course immunization is aimed to develop a platform for stakeholders to delve deeper on vaccine and its role as a primary preventive and how best to integrate into various healthcare schemes and programs for public health and meeting sustainable development goals.